NCOG-19. TUMOR INVASION INFLUENCES ON COGNITIVE FUNCTION IN RIGHT CEREBRAL HEMISPHERIC GLIOBLASTOMAS

Abstract INTRODUCTION Glioblastoma cells broadly infiltrate into surrounding brain parenchyma. In this study, we investigated the influence of tumor invasion on cognitive function in glioblastomas, using diffusion tensor imaging (DTI) . METHODS Participants were 32 patients with right hemispheric glioblastoma who underwent surgery Kanazawa University Hospital (mean age, 61.8 years). We evaluated differences p-map and q-map, which represent isotropy anisotropy patients' preoperative DTI. The divided two groups: less-invasive highly-invasive types. Following clinical demographic factors collected retrospectively: sex, volume enhanced lesion, location, methylation status MGMT promoter. Several kinds functions mediated by cerebral hemisphere assessed preoperatively. All these compared between groups. Moreover, voxel-based lesion symptom (VLSM) analyses performed to investigate regions relate decline invasion. RESULTS not significantly different Tumor infiltrated insula basal ganglia group. Verbal fluency, executive function, attention, social cognition impaired group (p=0.0067, 0.036, 0.0064, 0.030, respectively). Score verbal fluency lower when medial frontal region including cingulate cortex, deep part posterior middle inferior gyrus. Invasion sagittal stratum influenced deterioration attention function. CONCLUSION present study revealed that extending beyond causes such as glioblastoma.